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Broad spectrum antiviral drug inhibits a range of emerging coronaviruses — ScienceDaily

Researchers have long known that RNA viruses called coronaviruses cause the common cold and pneumonia. In the last two decades or so, though, researchers have found that these viruses can jump between animal and human hosts. In recent years, coronaviruses have caused lethal outbreaks of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome […]

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Characterizing ‘keyhole’ is first step to fighting obesity at cellular level: Team also launches development of potential small-molecule therapeutics — ScienceDaily

An international team has uncovered the potential to beat obesity at the cellular level, characterizing for the first time a complex, little-understood receptor type that, when activated, shuts off hunger. Jens Meiler, professor of chemistry and pharmacology at Vanderbilt University, said pharmaceutical companies long have attempted to develop a small-molecule drug that could do just […]

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Divide and conquer: Creating better medicines with fewer side effects — ScienceDaily

Today, a new study published in Science by Professors Yossi Paltiel of the Hebrew University of Jerusalem and Ron Naaman from the Weizmann Institute of Science describes a breakthrough technology with the power to create drugs with fewer unwanted side effects. Chemical compounds are made up of molecules. The most important molecules in biology are chiral molecules. […]

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Researchers reverse cognitive impairments in mice with dementia — ScienceDaily

Reversing memory deficits and impairments in spatial learning is a major goal in the field of dementia research. A lack of knowledge about cellular pathways critical to the development of dementia, however, has stood in the way of significant clinical advance. But now, researchers at the Lewis Katz School of Medicine at Temple University (LKSOM) […]

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BRIEF—EMA’s PRAC held public hearing on quinolone and fluoroquinolone

Lyrica, Pfizer’s blockbuster anticonvulsive treatment, is expected to come off-patent in December 2018, leading to a dramatic reduction in sales due to generic erosion. This will have a huge effect on Pfizer’s financial performances, with sales of Lyrica forecast to drop from $5 billion in 2018 to about $3 billion in 2019. Lyrica, an anticonvulsive […]

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Pfizer’s blockbuster drug Lyrica comes off-patent in 2018 – Pharmaceutical Technology

Lyrica, Pfizer’s blockbuster anticonvulsive treatment, is expected to come off-patent in December 2018, leading to a dramatic reduction in sales due to generic erosion. This will have a huge effect on Pfizer’s financial performances, with sales of Lyrica forecast to drop from $5 billion in 2018 to about $3 billion in 2019. Lyrica, an anticonvulsive […]

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FDA approves Suboxone generic variant to treat opioid dependence – Pharmaceutical Technology

The US Food and Drug Administration (FDA) has granted Mylan Technologies and Dr. Reddy’s Laboratories marketing approval for generic versions of Suboxone (buprenorphine and naloxone) sublingual film to treat opioid dependence. The approval enables the launch of various strengths of the drug in the US market, including 2mg/0.5mg, 4mg/1mg, 8mg/2mg, and 12mg/3mg variants. Buprenorphine suppresses […]

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Size, structure help poziotinib pose threat to deadly exon 20 lung cancer: MD Anderson Lung Cancer Moon Shot™ research matches drug to defiant mutation — ScienceDaily

A drug that failed to effectively strike larger targets in lung cancer hits a bulls-eye on the smaller target presented by a previously untreatable form of the disease, researchers at The University of Texas MD Anderson Cancer Center report in Nature Medicine. Their research provided the scientific underpinning for clinical trials under way of the drug […]

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Breakthrough technique combats cancer drug resistance: Researchers ‘turn off’ multi-drug resistance capabilities in cancer cells — ScienceDaily

Cancer (stock image). Credit: © Feng Yu / Fotolia The ability for cancer cells to develop resistance to chemotherapy drugs — known as multi-drug resistance — remains a leading cause for tumor recurrence and cancer metastasis, but recent findings offer hope that oncologists could one day direct cancer cells to “turn off” their resistance capabilities. […]

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Existing drug effective at preventing onset of type 1 diabetes in 60% of patients: Common blood pressure medication blocks molecule that can trigger the disease — ScienceDaily

Doctors may be able to block the onset of type 1 diabetes for up to 60% of patients. Credit: © designer491 / Fotolia A drug commonly used to control high blood pressure may also help prevent the onset of type 1 diabetes in up to 60 percent of those at risk for the disease, according […]

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