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Breakthrough technique combats cancer drug resistance: Researchers ‘turn off’ multi-drug resistance capabilities in cancer cells — ScienceDaily

The ability for cancer cells to develop resistance to chemotherapy drugs — known as multi-drug resistance — remains a leading cause for tumor recurrence and cancer metastasis, but recent findings offer hope that oncologists could one day direct cancer cells to “turn off” their resistance capabilities. New findings put forth by University of Maryland Fischell […]

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Broad spectrum antiviral drug inhibits a range of emerging coronaviruses — ScienceDaily

Researchers have long known that RNA viruses called coronaviruses cause the common cold and pneumonia. In the last two decades or so, though, researchers have found that these viruses can jump between animal and human hosts. In recent years, coronaviruses have caused lethal outbreaks of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome […]

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BRIEF—Opdivo first FDA-approved PD-1 inhibitor to offer every four-wee

The US Food and Drug Administration has approved Bristol-Myers Squibb’s supplemental Biologics License Application (sBLA) updating the Opdivo (nivolumab) dosing schedule to include 480mg infused every four weeks (Q4W) for a majority of approved indications in the treatment of various cancers. This approval will provide health care professionals the flexibility to customize patient care with […]

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CRISPR finds possible drug targets for ALS – Pharmaceutical Technology

Researchers at the Stanford University School of Medicine in the US have identified potential drug targets for amyotrophic lateral sclerosis (ALS) using CRISPR-Cas9 genome editing technology. ALS is a neurodegenerative disease characterised by abnormal protein build up caused by C9orf72 gene mutations that lead to blocked neuronal function and cell death. In an effort to […]

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FDA receives Sanofi’s sBLA of Dupixent for asthma – Pharmaceutical Technology

The US Food and Drug Administration (FDA) has accepted Sanofi’s supplemental biologics licence application (sBLA) for asthma drug Dupixent (dupilumab) for review. The application seeks approval for the use of the drug as an add-on maintenance treatment in select adults and adolescents aged 12 years and above suffering from moderate-to-severe asthma. Characterised by an imbalance […]

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Gilead study suggests HIV could be supressed without daily ART

Gilead Sciences has announced results from a preclinical study that suggest that it may be possible to suppress HIV without the need for daily antiretroviral therapy (ART). The preclinical study evaluated the efficacy of a combination of HIV drug candidates GS-9620 and PGT121 on eradicating simian-human immunodeficiency virus (SHIV) in non-human primates. Infected rhesus monkeys […]

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Full-length serotonin receptor structure seen for first time: High-powered microscope shows receptor at rest, with focus on drug development — ScienceDaily

A team of researchers from Case Western Reserve University School of Medicine have used Nobel prize-winning microscope technology to see full length serotonin receptors for the first time. The tiny proteins — approximately a billionth of a meter long — are common drug targets, despite limited available information about their structure. Now, new images published […]

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‘Virus-cracking’ molecules advance fight against hepatitis B — ScienceDaily

Indiana University researchers have made an important step forward in the design of drugs that fight the hepatitis B virus, which can cause liver failure and liver cancer. It’s estimated that 2 billion people worldwide have had a hepatitis B virus infection in their lifetime, with about 250 million — including 2 million Americans — […]

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How old antibiotic compounds could become tomorrow’s life-saving drugs — ScienceDaily

As the fight against drug-resistant infections continues, University of Leeds scientists are looking back at previously discarded chemical compounds, to see if any could be developed for new antibiotics. In the heyday of antibiotic development in the mid-20th century many different chemical compounds with antibacterial properties were examined, but only a small proportion were selected […]

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Botulinum-type toxins jump to a new kind of bacteria: Discovery of C. botulinum toxin in a strain of Enterococcus is raising concern — ScienceDaily

Enterococci are hardy microbes that thrive in the gastrointestinal tracts of nearly all land animals, including our own, and generally cause no harm. But their ruggedness has lately made them leading causes of multi-drug-resistant infections, especially in settings like hospitals where antibiotic use disrupts the natural balance of intestinal microbes. So the discovery of a […]

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