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8,000 new antibiotic combinations are surprisingly effective: Grouping 4 or 5 existing medications could help slow antibiotic-resistant bacteria — ScienceDaily

“We shouldn’t limit ourselves to just single drugs or two-drug combinations in our medical toolbox,” said Pamela Yeh (left), with Elif Tekin. Credit: Reed Hutchinson/UCLA Scientists have traditionally believed that combining more than two drugs to fight harmful bacteria would yield diminishing returns. The prevailing theory is that that the incremental benefits of combining three […]

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Sugar pills relieve pain for chronic pain patients: Placebo benefits can be predicted by brain anatomy and psychological traits — ScienceDaily

Doctors should consider treating chronic pain patients with sugar pills, new research suggests. Placebo pills relieve pain as effectively as drugs for half of chronic pain patients. Credit: © 18percentgrey / Fotolia Someday doctors may prescribe sugar pills for certain chronic pain patients based on their brain anatomy and psychology. And the pills will reduce […]

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New means to fight ‘un-killable’ bacteria in healthcare settings: Canadian scientists identify new cellular target to weaken P. aeruginosa — a severe threat to patients with cystic fibrosis — ScienceDaily

Dr. Dao Nguyen looking at Pseudomonas aeruginosa that has been listed among the “nightmare bacteria” by the Centers for Disease Control and Prevention (CDC) in the United States, with an estimated 51,000 healthcare-associated infections each year resulting in around 400 deaths. P. aeruginosa is a common cause of healthcare-associated infections such as pneumonia, bloodstream or urinary tract infections, and […]

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Possible cause for Alzheimer’s and traumatic brain injury discovered — ScienceDaily

Alzheimer’s definition (stock image). Credit: © Feng Yu / Fotolia Rutgers researchers have discovered a new mechanism that may contribute to Alzheimer’s disease and traumatic brain injury. They now hope to launch a clinical trial to test the treatment in humans. What causes Alzheimer’s is unknown, but a popular theory suggests a protein known as […]

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Gene and cell therapies: making manufacturing work – Pharmaceutical Technology

Gene and cell therapies are two of the fastest emerging areas of medicine. Comprising techniques such as gene editing and next-generation immunotherapy, they could treat – or even cure – a broad range of previously untreatable diseases. To understand their potential, we only need think of the examples that have already been approved. Kymriah, a […]

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FDA approves use of Merck’s HPV vaccine for up to age 45

The US Food and Drug Administration (FDA) has approved the use of Merck’s Gardasil 9 HPV vaccine in adults aged from 27 to 45 years. Gardasil 9 is indicated for the prevention of certain cancers and diseases caused by nine HPV types. The FDA originally approved Gardasil vaccine in 2006 for cancers and diseases caused […]

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Why some tuberculosis bacteria prove deadly: Single mutation protects TB bacteria from antibiotics, immune assault — ScienceDaily

Graduate student Nicole Howard works in a biosafety cabinet with the bacteria that cause tuberculosis (TB), while Shabaana Khader, Ph.D., looks on. Howard and Khader found that the same mutation that gives TB bacteria drug resistance also elicits a weaker immune response. Credit: Matt Miller People who fall sick with drug-resistant tuberculosis (TB) face daunting […]

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Drugs that stop mosquitoes catching malaria could help eradicate the disease — ScienceDaily

A male malaria parasite sexual stage becoming active — a process called exflagellation that happens inside the mosquito stomach. Credit: Sabrina Yahiya Researchers have identified compounds that could prevent malaria parasites from being able to infect mosquitoes, halting the spread of disease. Preventing transmission of malaria is a key part of efforts to eliminate the […]

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EMA and FDA find additional impurity in valsartan products

The European Medicines Agency (EMA) and the US Food and Drug Administration (FDA) have reported the presence of a second impurity in valsartan products. The new impurity is called N-Nitrosodiethylamine (NDEA) and it has been found in several batches of drugs with valsartan as the active pharmaceutical ingredient (API). Both the European and US regulatory authorities recalled certain valsartan […]

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Study finds daily aspirin does not decrease heart attack risk

Monash University in Australia has reported initial results from a large clinical trial (ASPREE) performed to investigate the benefits and risks of low, daily doses of aspirin in healthy people aged over 70 years. The randomised, double-blind, placebo-controlled trial, funded by the National Institute of Health (NIH) and led by the university, is being conducted […]

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