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Divide and conquer: Creating better medicines with fewer side effects — ScienceDaily

Today, a new study published in Science by Professors Yossi Paltiel of the Hebrew University of Jerusalem and Ron Naaman from the Weizmann Institute of Science describes a breakthrough technology with the power to create drugs with fewer unwanted side effects. Chemical compounds are made up of molecules. The most important molecules in biology are chiral molecules. […]

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Researchers reverse cognitive impairments in mice with dementia — ScienceDaily

Reversing memory deficits and impairments in spatial learning is a major goal in the field of dementia research. A lack of knowledge about cellular pathways critical to the development of dementia, however, has stood in the way of significant clinical advance. But now, researchers at the Lewis Katz School of Medicine at Temple University (LKSOM) […]

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Combining antibiotics changes their effectiveness

The effectiveness of antibiotics can be altered by combining them with each other, non-antibiotic drugs or even with food additives. Depending on the bacterial species, some combinations stop antibiotics from working to their full potential whilst others begin to defeat antibiotic resistance, report EMBL researchers and collaborators in Nature on July 4. In the first large-scale screening […]

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After 60 years, scientists uncover how thalidomide produced birth defects — ScienceDaily

More than 60 years after the drug thalidomide caused birth defects in thousands of children whose mothers took the drug while pregnant, scientists at Dana-Farber Cancer Institute have solved a mystery that has lingered ever since the dangers of the drug first became apparent: how did the drug produce such severe fetal harm? The answer, […]

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Novartis’ migraine drug Aimovig approved by European Commision

Novartis has obtained approval from the European Commission (EC) for the use of Aimovig (erenumab) to prevent migraine in adults who experience four or more migraine days a month. Aimovig is designed to block the calcitonin gene-related peptide receptor (CGRP-R), which is associated with mediation of the incapacitating migraine pain. The drug is specifically developed […]

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The FDA’s approach to tackling injectable drug shortages – Pharmaceutical Technology

The FDA will create a Drug Shortages Task Force to address drug manufacturing problems, FDA Commissioner Scott Gottlieb has announced. Gottlieb also called for pharma companies to invest in more production capacity. In a July 12 statement, Commissioner Gottlieb noted low-profit generic medicines are especially likely to suffer shortages. Many of these are sterile parenteral […]

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Broad spectrum antiviral drug inhibits a range of emerging coronaviruses — ScienceDaily

Researchers have long known that RNA viruses called coronaviruses cause the common cold and pneumonia. In the last two decades or so, though, researchers have found that these viruses can jump between animal and human hosts. In recent years, coronaviruses have caused lethal outbreaks of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome […]

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Characterizing ‘keyhole’ is first step to fighting obesity at cellular level: Team also launches development of potential small-molecule therapeutics — ScienceDaily

An international team has uncovered the potential to beat obesity at the cellular level, characterizing for the first time a complex, little-understood receptor type that, when activated, shuts off hunger. Jens Meiler, professor of chemistry and pharmacology at Vanderbilt University, said pharmaceutical companies long have attempted to develop a small-molecule drug that could do just […]

Posted in Research, Science | Comments Off on Characterizing ‘keyhole’ is first step to fighting obesity at cellular level: Team also launches development of potential small-molecule therapeutics — ScienceDaily

Divide and conquer: Creating better medicines with fewer side effects — ScienceDaily

Today, a new study published in Science by Professors Yossi Paltiel of the Hebrew University of Jerusalem and Ron Naaman from the Weizmann Institute of Science describes a breakthrough technology with the power to create drugs with fewer unwanted side effects. Chemical compounds are made up of molecules. The most important molecules in biology are chiral molecules. […]

Posted in Drug | Comments Off on Divide and conquer: Creating better medicines with fewer side effects — ScienceDaily

Researchers reverse cognitive impairments in mice with dementia — ScienceDaily

Reversing memory deficits and impairments in spatial learning is a major goal in the field of dementia research. A lack of knowledge about cellular pathways critical to the development of dementia, however, has stood in the way of significant clinical advance. But now, researchers at the Lewis Katz School of Medicine at Temple University (LKSOM) […]

Posted in Research | Comments Off on Researchers reverse cognitive impairments in mice with dementia — ScienceDaily