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New study identifies and blocks molecule that maintains sciatic nerve pain – Pharmaceutical Technology

by JMC on March 4, 2016

A study conducted by Hiroshima University in Japan has identified and blocked a specific molecule involved in maintaining pain after a nerve injury.

Researchers at the university initiated investigation of sciatic nerve pain as part of their long-term studies of the central nervous system.

Sciatic nerve pain, or sciatica, causes pain in the lower back, buttocks, or back of the leg and is often caused by a herniated disc in the spine or a pinched nerve. Similar pain can occur in different nerves in patients with cancer or diabetic neuropathy.

During the study, researchers administered a drug to mice with an injury to their sciatic nerve.

Following multiple injections of a drug that blocks the activity of a molecule called high-mobility group box-1 (HMGB1), researchers found significant decrease in pain in mice.

Source: New study identifies and blocks molecule that maintains sciatic nerve pain – Pharmaceutical Technology

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