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New computational tool enables prediction of key functional sites in proteins based on structure

A new technology that uses a protein’s structure to predict the inner wiring that controls the protein’s function and dynamics is now available for scientists to utilize. The tool, developed by researchers at Penn State, may be useful for protein engineering and drug design. Nikolay Dokholyan, professor of pharmacology at Penn State College of Medicine, […]

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Genetic study of proteins is a breakthrough in drug development for complex diseases

An innovative genetic study of blood protein levels, led by researchers in the MRC Integrative Epidemiology Unit (MRC-IEU) at the University of Bristol, has demonstrated how genetic data can be used to support drug target prioritisation by identifying the causal effects of proteins on diseases. Working in collaboration with pharmaceutical companies, Bristol researchers have developed […]

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New drug could stop deadly superbug, save tens of thousands of lives

Vancomycin-resistant enterococcus (VRE) is among the leading causes of hospital-acquired infections in the United States. An estimated 20,000 people in the U.S. become infected with it each year, and nearly 10% of people who get it die from it. These superbugs typically develop from infections in the intestinal tract, where the bacteria become resistant to […]

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Researchers discover a specific brain circuit damaged by social isolation during childhood

Loneliness is recognized as a serious threat to mental health. Even as our world becomes increasingly connected over digital platforms, young people in our society are feeling a growing sense of isolation. The COVID-19 pandemic, which forced many countries to implement social distancing and school closures, magnifies the need for understanding the mental health consequences […]

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Stroke Warning Signs Often Occur Hours Or Days Before Attack

ST. PAUL, Minn. – Warning signs of an ischemic stroke may be evident as early as seven days before an attack and require urgent treatment to prevent serious damage to the brain, according to a study of stroke patients published in the March 8, 2005 issue of Neurology, the scientific journal of the American Academy […]

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Antiviral used to treat cat coronavirus also works against SARS-CoV-2

Researchers at the University of Alberta are preparing to launch clinical trials of a drug used to cure a deadly disease caused by a coronavirus in cats that they expect will also be effective as a treatment for humans against COVID-19. “In just two months, our results have shown that the drug is effective at […]

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How cancer drugs find their targets could lead to a new toolset for drug development — ScienceDaily

In the watery inside of a cell, complex processes take place in tiny functional compartments called organelles. Energy-producing mitochondria are organelles, as is the frilly golgi apparatus, which helps to transport cellular materials. Both of these compartments are bound by thin membranes. But in the past few years, research at Whitehead Institute and elsewhere has […]

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Breakthrough discovery to transform prostate cancer treatment — ScienceDaily

A novel formulation of the prostate cancer drug abiraterone acetate — currently marketed as Zytiga — will dramatically improve the quality of life for people suffering from prostate cancer, as pre-clinical trials by the University of South Australia show the new formulation improves the drug’s effectiveness by 40 per cent. Developed by Professor Clive Prestidge’s […]

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Existing drugs can prevent SARS-CoV-2 from hijacking cells — ScienceDaily

An international team of researchers has analysed how SARS-CoV-2, the virus that causes COVID-19, hijacks the proteins in its target cells. The research, published in the journal Cell, shows how the virus shifts the cell’s activity to promote its own replication and to infect nearby cells. The scientists also identified seven clinically approved drugs that could […]

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Compounds halt SARS-CoV-2 replication by targeting key viral enzyme: Four promising antiviral drug candidates identified and analyzed in preclinical study — ScienceDaily

As the death toll from the COVID-19 pandemic mounts, scientists worldwide continue their push to develop effective treatments and a vaccine for the highly contagious respiratory virus. University of South Florida Health (USF Health) Morsani College of Medicine scientists recently worked with colleagues at the University of Arizona College of Pharmacy to identify several existing […]

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