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Unlocking ‘the shape of water’ in mechanisms of antibiotic resistance

New high-resolution structures of the bacterial ribosome determined by researchers at the University of Illinois Chicago show that a single water molecule may be the cause — and possible solution — of antibiotic resistance. The findings of the new UIC study are published in the journal Nature Chemical Biology. Pathogenic germs become resistant to antibiotics when […]

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Using targeted microbubbles to administer toxic cancer drugs

New research has shown how microbubbles carrying powerful cancer drugs can be guided to the site of a tumour using antibodies. Microbubbles are small manufactured spheres half the size of a red blood cell — and scientists believe they can be used to transport drugs to highly specific locations within the body. In a paper […]

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Tomatoes offer affordable source of Parkinson’s disease drug

Scientists have produced a tomato enriched in the Parkinson’s disease drug L-DOPA in what could become a new, affordable source of one of the world’s essential medicines. The development of the genetically modified (GM) tomato has implications for developing nations where access to pharmaceutical drugs is restricted. This novel use of tomato plants as a […]

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New class of antibiotics active against a wide range of bacteria

Wistar Institute scientists have discovered a new class of compounds that uniquely combine direct antibiotic killing of pan drug-resistant bacterial pathogens with a simultaneous rapid immune response for combatting antimicrobial resistance (AMR). These finding were published today in Nature. The World Health Organization (WHO) has declared AMR as one of the top 10 global public health […]

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Global trial reveals life saving drug for acute myeloid leukemia

A landmark paper published today in the New England Journal of Medicine describes the results from a global trial across 148 sites in 23 countries, showing a 30 per cent improvement in survival in patients with acute myeloid leukemia (AML). The Phase 3 clinical trial called QUAZAR, showed that a drug, called CC-486, significantly improved survival in […]

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Gritstone, NIAID enter clinical trial agreement for next-gen Covid-19 vaccine

Gritstone has entered into a clinical trial agreement with the US National Institutes of Health (NIH) unit National Institute of Allergy and Infectious Diseases (NIAID) to advance its Covid-19 programme, CORAL, for developing a second-generation vaccine. Gritstone has entered into a clinical trial agreement with the US National Institutes of Health (NIH) unit the National […]

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Oral drug blocks SARS-CoV-2 transmission, researchers find

Treatment of SARS-CoV-2 infection with a new antiviral drug, MK-4482/EIDD-2801 or Molnupiravir, completely suppresses virus transmission within 24 hours, researchers in the Institute for Biomedical Sciences at Georgia State University have discovered. The group led by Dr. Richard Plemper, Distinguished University Professor at Georgia State, originally discovered that the drug is potent against influenza viruses. […]

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Anti-antibiotic’ allows for use of antibiotics without driving resistance

An inexpensive, FDA-approved drug — cholestyramine — taken in conjunction with an antibiotic prevents the antibiotic from driving antimicrobial resistance, according to new research by scientists at Penn State and the University of Michigan. The team’s findings appear today (Dec. 1) in the journal eLife. “Antimicrobial resistance is a serious problem that has led to people […]

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Using targeted microbubbles to administer toxic cancer drugs

New research has shown how microbubbles carrying powerful cancer drugs can be guided to the site of a tumour using antibodies. Microbubbles are small manufactured spheres half the size of a red blood cell — and scientists believe they can be used to transport drugs to highly specific locations within the body. In a paper […]

Posted in Cancer, Research | Comments Off on Using targeted microbubbles to administer toxic cancer drugs

Tomatoes offer affordable source of Parkinson’s disease drug

Scientists have produced a tomato enriched in the Parkinson’s disease drug L-DOPA in what could become a new, affordable source of one of the world’s essential medicines. The development of the genetically modified (GM) tomato has implications for developing nations where access to pharmaceutical drugs is restricted. This novel use of tomato plants as a […]

Posted in Research, Science | Comments Off on Tomatoes offer affordable source of Parkinson’s disease drug