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Operations in pharmaceutical industry: simplification and behaviour change

NSF International’s Pharmaceutical executive director Jim Morris’s webinar, Implementing a Simplification Strategy, describes several ways to increase the efficiency of a production plant by helping operators execute tasks with greater consistency and confidence, and less effort. A key principle is to ensure a reduction of cognitive load for personnel who work in the operational side of […]

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Novartis’ combination asthma drug meets endpoints in Phase II study

QMF149 combines a long-acting beta antagonist with an anti-inflammatory drug. Credit: FSP Vintage Collection. Swiss drug maker Novartis has announced its investigational, combination asthma drug QMF149 met both its primary and secondary endpoints in the Phase III QUARTZ trial. QMF149 is a once-daily, low dose combination treatment containing indacaterol acetate (ICD), a long-acting beta agonist, […]

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Lynparza reduces PFS in germline BRCA-mutated pancreatic cancer

AstraZeneca and Merck have announced that Lynparza (olaparib) demonstrated significant improvement in progression-free survival (PFS), compared to placebo, in germline BRCA-mutated metastatic .adenocarcinoma of the pancreas. In the Phase III POLO trial, researches only studied patients whose disease had not progressed following platinum-based chemotherapy, which is the current the standard of care. Lynparza improved time […]

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Pembrolizumab trumps chemotherapy in recurrent head and neck cancer

Research has shown that immunotherapy pembrolizumab alone and in combination with chemotherapy is a more efficacious first line treatment for head and neck cancer that has returned than aggressive chemotherapy. The research was led by the Institute of Cancer Research (ICR), London and The Royal Marsden NHS Foundation Trust, but carried out across 206 sites […]

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Targeted therapy proves effective against aggressive rare blood cancer: Clinical study treating BPDCN with tagraxofusp led to first FDA approval for the disease

A multi-institutional clinical trial has given good results for a targeted therapy to treat a rare, aggressive blood cancer known as blastic plasmacytoid dendritic-cell neoplasm (BPDCN). Details on the trial, which supported Food and Drug Administration approval of the tagraxofusp therapy in December 2018, have been published in the New England Journal of Medicine. Diagnosed in […]

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Scientists reproduce complete copy of ‘anti-tumor antibiotic’: Breakthrough reveals new ways to combat drug-resistant bacteria and fight cancer 

After 20 years of dedicated research, scientists have cracked the chemical code of an incredibly complex ‘anti-tumour antibiotic’ known to be highly effective against cancer cells as well as drug-resistant bacteria, and have reproduced it synthetically in the lab for the first time. This major breakthrough and world-first could hail a new era in the […]

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More evidence that blood tests can detect the risk of Alzheimer’s — ScienceDaily

A new study confirms that a simple blood test can reveal whether there is accelerating nerve cell damage in the brain. The researchers analysed neurofilament light protein (NFL) in blood samples from patients with Alzheimer’s disease. Recently published in JAMA Neurology, the study suggests that the NFL concentration in the blood could be able to indicate […]

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New pill can deliver insulin through the stomach — ScienceDaily

An MIT-led research team has developed a drug capsule that could be used to deliver oral doses of insulin, potentially replacing the injections that people with type 1 diabetes have to give themselves every day. About the size of a blueberry, the capsule contains a small needle made of compressed insulin, which is injected after […]

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Electrical signals kick off flatworm regeneration — ScienceDaily

Unlike most multicellular animals, planarian flatworms can regrow all their body parts after they are removed. This makes them a good model for studying the phenomenon of tissue regeneration. They are also useful for exploring fundamental questions in developmental biology about what underlies large-scale anatomical patterning. In a study publishing March 5 in Biophysical Journal, scientists […]

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Vast leukemia dataset could help researchers match therapies to patients — ScienceDaily

After years of work, researchers are releasing a massive dataset detailing the molecular makeup of tumor cells from more than 500 patients with an aggressive blood cancer called acute myeloid leukemia (AML). The dataset includes how hundreds of individual patients’ cells responded to a broad panel of drugs in laboratory screens. It is the largest […]

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