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Liquid biopsies reveal genetic alterations linked to cancer drug resistance — ScienceDaily

Many patients see their tumors shrink in response to a drug, only to have them come back with a vengeance as they evolve to fend off the treatment. Oncologists want to be able to quickly detect cancer drug resistance as it emerges in their patients and identify another drug the tumors will still respond to. […]

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Cancer drugs don’t always work as intended, researchers warn — ScienceDaily

Scientists at Cold Spring Harbor Laboratory (CSHL) have identified 10 cancer drugs currently in clinical trials that do not work how clinicians thought they would. In identifying what went wrong, experts can now work to improve drug discovery and personalized medicine. The discovery started out with an entirely different goal. Over the past few years, […]

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Scientists can now manipulate brain cells using smartphone — ScienceDaily

A team of scientists in Korea and the United States have invented a device that can control neural circuits using a tiny brain implant controlled by a smartphone. Researchers, publishing in Nature Biomedical Engineering, believe the device can speed up efforts to uncover brain diseases such as Parkinson’s, Alzheimer’s, addiction, depression, and pain. The device, using […]

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Scientists have developed a method to test whether an infection is resistant to common antibiotics — ScienceDaily

Scientists have developed a method to test whether an infection is resistant to common antibiotics. Beta-lactam antibiotics (such as penicillin) are one of the most important classes of antibiotics, but resistance to them has grown to such an extent that doctors often avoid prescribing them in favour of stronger drugs. Scientists from the University of […]

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E. coli superbug strains can persist in healthy women’s guts — ScienceDaily

A recent study of over 1,000 healthy women with no symptoms of urinary tract infections showed nearly 9 percent carried multi-drug resistant Escherichia coli strains in their guts. This is of clinical concern because disease-causing E. coli bacteria can transfer from the digestive tract to the female urinary tract via the urethra, the urine duct, which is […]

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US senators introduce bipartisan bill to lower drug prices

US Senate Finance Committee chairman Chuck Grassley and ranking member Ron Wyden have introduced a bipartisan bill aimed at lowering drug prices in the country. The Prescription Drug Pricing Reduction Act (PDPRA) asks for penalisation of pharmaceutical companies that increase Medicare prices more than inflation. Drugmakers will require rebates to be paid equivalent to the […]

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FDA approves nine generics of Pfizer’s Lyrica drug

SHARE Lyrica is a prescription medicine cleared by the FDA for the treatment of various pain indications. Credit: Vaccinationist. The US Food and Drug Administration (FDA) has approved nine generic versions of Pfizer’s nerve pain drug Lyrica (pregabalin), which are the first generics approved for the medication. Lyrica is a prescription medicine cleared by the […]

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Myovant reports uterine fibroid combination therapy results

UK healthcare company Myovant Sciences has announced positive results from LIBERTY 2, its second Phase III study of relugolix combination therapy. The trial met its primary efficacy endpoint with a 71.2% response rate, as well assix key secondary endpoints in women with uterine fibroids. The Phase III programme consisted of two duplicate, pivotal clinical studies […]

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BMS’ Opdivo fails to meet primary endpoint in NSCLC

Bristol-Myers Squibb (BMS) has announced that its immunotherapy Opvido (nivolumab) plus chemotherapy failed to meet its primary endpoint of overall survival (OS) in the Phase III CheckMate-227 trial of patients with first-line non-squamous non-small cell lung cancer (NSCLC). Opdivo is a PD-1 immune checkpoint inhibitor that harnesses the body’s immune system to fight cancer. It […]

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Operations in pharmaceutical industry: simplification and behaviour change

NSF International’s Pharmaceutical executive director Jim Morris’s webinar, Implementing a Simplification Strategy, describes several ways to increase the efficiency of a production plant by helping operators execute tasks with greater consistency and confidence, and less effort. A key principle is to ensure a reduction of cognitive load for personnel who work in the operational side of […]

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