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Medicine for multiple sclerosis patients inhibits coronavirus — at least in a test tube

An antiviral medication which effectively inhibits replication of the coronavirus causing the COVID-19 and, at the same time, fights the immune reaction that is killing COVID-19 patients around the world. This is the hope of a group of researchers headed by Christian Kanstrup Holm and David Olagnier who are behind a newly-published new study in […]

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Experimental glioblastoma therapy shows curative powers in mice models

Houston Methodist researchers found that mice harboring human glioblastoma tumors in their brains had greatly enhanced survival and weight gain when given a newly developed prodrug. This mitochondrial-targeted prodrug — an inactive compound that cancer cells selectively metabolize to produce an active toxic drug — also greatly improves outcomes when coupled with standard therapies of […]

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Scientists engineer bacteria-killing molecules from wasp venom

A team led by scientists in the Perelman School of Medicine at the University of Pennsylvania has engineered powerful new antimicrobial molecules from toxic proteins found in wasp venom. The team hopes to develop the molecules into new bacteria-killing drugs, an important advancement considering increasing numbers of antibiotic-resistant bacteria which can cause illness such as […]

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34% of older adults in the US are prescribed potentially inappropriate drugs

The prescription of potentially inappropriate medications to older adults is linked to increased hospitalizations, and it costs patients, on average, more than $450 per year, according to a new University at Buffalo study. The research, which sought to determine the impact of potentially inappropriate medications on health care utilization and costs in the United States, […]

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Moderna partners with Takeda for Covid-19 vaccines supply to Japan

Moderna has announced that the Ministry of Health, Labour and Welfare of Japan (MHLW) and Takeda Pharmaceutical agreed to purchase and distribute 50 million doses of its Covid-19 vaccine candidate, mRNA-1273. Moderna has announced that the Ministry of Health, Labour and Welfare of Japan (MHLW) and Takeda Pharmaceutical agreed to purchase and distribute 50 million […]

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NICE recommends new treatment from Novo Nordisk for obesity

National Institute for Health and Care Excellence (NICE) has recommended a new treatment option developed by Novo Nordisk for adults with obesity and non-diabetic hyperglycaemia. NICE recommends Novo Nordisk treatment for adults with obesity Saxenda is recommended with a reduced-calorie diet and increased physical activity. Credit: Novo Nordisk Inc. Share Article National Institute for Health […]

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New computational tool enables prediction of key functional sites in proteins based on structure

A new technology that uses a protein’s structure to predict the inner wiring that controls the protein’s function and dynamics is now available for scientists to utilize. The tool, developed by researchers at Penn State, may be useful for protein engineering and drug design. Nikolay Dokholyan, professor of pharmacology at Penn State College of Medicine, […]

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Genetic study of proteins is a breakthrough in drug development for complex diseases

An innovative genetic study of blood protein levels, led by researchers in the MRC Integrative Epidemiology Unit (MRC-IEU) at the University of Bristol, has demonstrated how genetic data can be used to support drug target prioritisation by identifying the causal effects of proteins on diseases. Working in collaboration with pharmaceutical companies, Bristol researchers have developed […]

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New drug could stop deadly superbug, save tens of thousands of lives

Vancomycin-resistant enterococcus (VRE) is among the leading causes of hospital-acquired infections in the United States. An estimated 20,000 people in the U.S. become infected with it each year, and nearly 10% of people who get it die from it. These superbugs typically develop from infections in the intestinal tract, where the bacteria become resistant to […]

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Researchers discover a specific brain circuit damaged by social isolation during childhood

Loneliness is recognized as a serious threat to mental health. Even as our world becomes increasingly connected over digital platforms, young people in our society are feeling a growing sense of isolation. The COVID-19 pandemic, which forced many countries to implement social distancing and school closures, magnifies the need for understanding the mental health consequences […]

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