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Artificial intelligence yields new antibiotic: A deep-learning model identifies a powerful new drug that can kill many species of antibiotic-resistant bacteria — ScienceDaily

Using a machine-learning algorithm, MIT researchers have identified a powerful new antibiotic compound. In laboratory tests, the drug killed many of the world’s most problematic disease-causing bacteria, including some strains that are resistant to all known antibiotics. It also cleared infections in two different mouse models. The computer model, which can screen more than a […]

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Drug meant for Ebola may also work against coronaviruses: Understanding how drugs work is an important step in developing new treatments for COVID-19 — ScienceDaily

A group of University of Alberta researchers who have discovered why the drug remdesivir is effective in treating the coronaviruses that cause Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS) expect it might also be effective for treating patients infected with the new COVID-19 strain. “Even if you know a drug works, […]

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Preventing spread of SARS coronavirus-2 in humans: Infection researchers identify potential drug — ScienceDaily

Several coronaviruses circulate worldwide and constantly infect humans, which normally caused only mild respiratory disease. Currently, however, we are witnessing a worldwide spread of a new coronavirus with more than 90,000 confirmed cases and over 3,000 deaths. The new virus has been named SARS coronavirus-2 and has been transmitted from animals to humans. It causes […]

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New way to test for drug resistant infections: Scientists have developed a method to test whether an infection is resistant to common antibiotics — ScienceDaily

Scientists have developed a method to test whether an infection is resistant to common antibiotics. Beta-lactam antibiotics (such as penicillin) are one of the most important classes of antibiotics, but resistance to them has grown to such an extent that doctors often avoid prescribing them in favour of stronger drugs. Scientists from the University of […]

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Deadly ‘superbugs’ destroyed by molecular drills — ScienceDaily

Molecular drills have gained the ability to target and destroy deadly bacteria that have evolved resistance to nearly all antibiotics. In some cases, the drills make the antibiotics effective once again. Researchers at Rice University, Texas A&M University, Biola University and Durham (U.K.) University showed that motorized molecules developed in the Rice lab of chemist […]

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Japan approves ViiV’s two drug regimen Dovato for HIV

ViiV Healthcare’s human immunodeficiency virus (HIV) drug Dovato (dolutegravir 50mg/lamivudine 300mg) has been approved by the Japanese Ministry of Health, Labour and Welfare (MHLW). Dovato is a once-daily, single pill, two-drug regimen approved to treat adults and adolescents aged over 12 with HIV type 1 (HIV-1) infection who weigh more than 40kg. The drug is […]

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Novo Nordisk secures FDA expanded indication for Ozempic

The US Food and Drug Administration (FDA) has approved a new indication for Novo Nordisk’s Ozempic (semaglutide). The once-weekly injection is now indicated to reduce the risk of major adverse cardiovascular events (MACE), such as non-fatal heart attack or stroke and cardiovascular death, in adults with type 2 diabetes and established cardiovascular disease (CVD). FDA […]

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FDA grants Clovis’ Rubraca fast track designation for prostate cancer

By Allie Nawrat Colorado-based Clovis Oncology has received fast track designation from the US Food and Drug Administration (FDA) for Rubraca (rucaparib) as a monotherapy for BRCA1/2-mutant recurrent, metastatic castrate-resistant prostate cancer (mCRPC) adult patients. Rubraca is an oral, small molecule inhibitor of poly ADP-ribose polymerase (PARP) 1, 2 and 3, being developed in multiple solid […]

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Mitochondria are the ‘canary in the coal mine’ for cellular stress: How some cancers resist chemotherapy — ScienceDaily

Mitochondria, tiny structures present in most cells, are known for their energy-generating machinery. Now, Salk researchers have discovered a new function of mitochondria: they set off molecular alarms when cells are exposed to stress or chemicals that can damage DNA, such as chemotherapy. The results, published online in Nature Metabolism on December 9, 2019, could lead to […]

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Deadly ‘superbugs’ destroyed by molecular drills — ScienceDaily

Molecular drills have gained the ability to target and destroy deadly bacteria that have evolved resistance to nearly all antibiotics. In some cases, the drills make the antibiotics effective once again. Researchers at Rice University, Texas A&M University, Biola University and Durham (U.K.) University showed that motorized molecules developed in the Rice lab of chemist […]

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