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Taking inventory of which drugs the world is using to treat COVID-19: Researchers create database to categorize off-label use and look for promising leads — ScienceDaily

With doctors and researchers around the world searching for effective treatments for COVID-19, many drugs approved to treat other diseases are being used in hopes that they’ll be effective against the virus, a use that’s known as “off-label.” New research from the Perelman School of Medicine at the University of Pennsylvania catalogued every use documented […]

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Researchers urge halt in prescribing hydroxycholoroquine for COVID-19 — ScienceDaily

The sacred oath taken by physicians during graduation from medical school to “First do no harm,” the first words of the Hippocratic Oath, provides a strong impetus for a commentary just published in The American Journal of Medicine. Researchers from Florida Atlantic University’s Schmidt College of Medicine and collaborators from the University of Wisconsin School of […]

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New pill could prevent anaphylaxis in people with food, drug allergies: Drug would be the first known treatment to prevent anaphylaxis — ScienceDaily

For someone with a food or drug allergy, the risk of life-threatening anaphylactic shock lurks around every corner. A new Northwestern Medicine study shows there might be a pill that can be taken proactively to prevent mild to life-threatening anaphylaxis, no matter the cause. Anaphylaxis is a severe, potentially life-threatening systemic allergic reaction that can […]

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3D Printing in Healthcare: Technology Trends

3D printing, also known as additive manufacturing, is the process of joining materials to make objects from 3D model data, typically created by building one layer upon the previous layer. This contrasts with subtractive manufacturing, in which parts of a block of material are selectively removed. 3D printing is used across a range of sectors, […]

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Intravacc forms alliance to develop intranasal Covid-19 vaccine

Dutch research and development vaccine institute Intravacc has collaborated with Wageningen Bioveterinary Research (WBVR) and Utrecht University to develop an intranasal vaccine against Covid-19. The alliance will combine Intravacc’s vaccine development technology, WBVR’s viral vector and animal technologies, along with Utrecht University’s coronavirus expertise. Intravacc noted that the intranasal vaccine will contain a Newcastle disease […]

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Better understanding of nature’s nanomachines may help in design of future drugs — ScienceDaily

Many of the drugs and medicines that we rely on today are natural products taken from microbes like bacteria and fungi. Within these microbes, the drugs are made by tiny natural machines — mega-enzymes known as nonribosomal peptide synthetases (NRPSs). A research team led by McGill University has gained a better understanding of the structures […]

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Chemists working on drugs to treat COVID-19 — ScienceDaily

In the wake of the novel coronavirus pandemic, Texas A&M University chemist Wenshe Ray Liu and his research team have focused their lab solely on searching for drugs to treat COVID-19. The Liu group was the first to identify the antiviral drug remdesivir as a viable medicine to treat COVID-19 in a research study published […]

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COVID-19 drug lead treatments identified — ScienceDaily

An international team of researchers has tested more than 10,000 compounds to identify six drug candidates that may help treat COVID-19. The research, involving University of Queensland scientist Professor Luke Guddat, tested the efficacy of approved drugs, drug candidates in clinical trials and other compounds. “Currently there are no targeted therapeutics or effective treatment options […]

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Super-charging drug development for COVID-19: Cell-free production method scales up yield by 5,000 times — ScienceDaily

Researchers are ramping up production of a promising drug that has proven effective in obliterating SARS-CoV in cellular cultures. The team hopes that the drug might also be effective in the fight against SARS’s close genetic cousin, the novel coronavirus (COVID-19). Led by Northwestern University and ShanghaiTech University, the team has produced the promising molecule, […]

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‘Directing’ evolution to identify potential drugs earlier in discovery — ScienceDaily

Scientists have developed a technique that could significantly reduce the time of discovering potential new antibody-based drugs to treat disease. Antibodies are produced by the body in response to the presence of a disease-causing agent. They can also be synthesised in the laboratory to mimic natural antibodies and are used to treat a number of […]

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