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Vast leukemia dataset could help researchers match therapies to patients 

After years of work, researchers are releasing a massive dataset detailing the molecular makeup of tumor cells from more than 500 patients with an aggressive blood cancer called acute myeloid leukemia (AML). The dataset includes how hundreds of individual patients’ cells responded to a broad panel of drugs in laboratory screens. It is the largest […]

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US government’s new rule targets drug industry’s rebate system

US Department of Health & Human Services (HHS) has proposed a new rule to end drug rebates and push direct discounts to patients across the country. The move is intended to lower the prices of prescription drugs and out-of-pocket costs, while improving transparency in the market. If passed into law, the new rule would eliminate the discounts […]

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Mylan’s generic of asthma drug Advair receives FDA approval

The US Food and Drug Administration (FDA) has approved Mylan’s generic version of GlaxoSmithKline’s (GSK) asthma treatment Advair Diskus (fluticasone propionate and salmeterol inhalation powder). Dubbed Wixela Inhub, Mylan’s treatment is the first generic of Advair. The FDA approved three dosages of the generic inhaler for twice-daily asthma therapy in patients aged four years and […]

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Vast leukemia dataset could help researchers match therapies to patients — ScienceDaily

After years of work, researchers are releasing a massive dataset detailing the molecular makeup of tumor cells from more than 500 patients with an aggressive blood cancer called acute myeloid leukemia (AML). The dataset includes how hundreds of individual patients’ cells responded to a broad panel of drugs in laboratory screens. It is the largest […]

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DelSiTech partners with Innovare to create long-acting HIV drug

Finnish drug delivery company DelSiTech has signed a licensing agreement with Mexico-based pharmaceutical group Innovare to develop a long-acting human immunodeficiency virus (HIV) therapy. Innovare will leverage DelSiTech’s Silica Matrix drug delivery platform, which controls the release of the drug and can thermostabilise products for many years, for its peptide membrane fusion inhibitor that targets […]

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8,000 new antibiotic combinations are surprisingly effective: Grouping 4 or 5 existing medications could help slow antibiotic-resistant bacteria — ScienceDaily

Scientists have traditionally believed that combining more than two drugs to fight harmful bacteria would yield diminishing returns. The prevailing theory is that that the incremental benefits of combining three or more drugs would be too small to matter, or that the interactions among the drugs would cause their benefits to cancel one another out. […]

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Sugar pills relieve pain for chronic pain patients: Placebo benefits can be predicted by brain anatomy and psychological traits — ScienceDaily

Someday doctors may prescribe sugar pills for certain chronic pain patients based on their brain anatomy and psychology. And the pills will reduce their pain as effectively as any powerful drug on the market, according to new research. Northwestern Medicine scientists have shown they can reliably predict which chronic pain patients will respond to a […]

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New means to fight ‘un-killable’ bacteria in healthcare settings: Canadian scientists identify new cellular target to weaken P. aeruginosa — a severe threat to patients with cystic fibrosis — ScienceDaily

Scientists at the Research Institute of the McGill University Health Centre (RI-MUHC) have identified new means of fighting drug-tolerant bacteria, a growing global threat as menacing as drug-resistant microbes. Little is known about the mechanisms leading to tolerance, a strategy that makes bacteria “indifferent” to antibiotics and almost “un-killable,” which results in chronic infections extremely […]

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Gene and cell therapies: making manufacturing work – Pharmaceutical Technology

Gene and cell therapies are two of the fastest emerging areas of medicine. Comprising techniques such as gene editing and next-generation immunotherapy, they could treat – or even cure – a broad range of previously untreatable diseases. To understand their potential, we only need think of the examples that have already been approved. Kymriah, a […]

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FDA approves use of Merck’s HPV vaccine for up to age 45

The US Food and Drug Administration (FDA) has approved the use of Merck’s Gardasil 9 HPV vaccine in adults aged from 27 to 45 years. Gardasil 9 is indicated for the prevention of certain cancers and diseases caused by nine HPV types. The FDA originally approved Gardasil vaccine in 2006 for cancers and diseases caused […]

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