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Scientists discover how to trap cancer cells before they spread

by JMC on October 9, 2015

At the original tumor site, cancer cells cause connective-tissue cells called fibroblasts to stiffen the surrounding tissue. This enables cancer cells to grip to it- allowing them to tunnel through to the blood stream and spread around the body.

The research team behind the results showed that adding experimental drugs can reprogramme fibroblasts and stop them from ‘stiffening’ the tissue around tumors. This healthy tissue trapped the cancer cells, blocking their movement away from the tumor.

In this Novo Nordisk Foundation and Cancer Research UK funded study, the team showed that targeting fibroblasts in a cancer model reduced the movement of cancer cells from the tumor to the lungs and liver through the blood stream.

Read full article here.

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